Article on NIH Funding

by Denise Kirschner

There is a heightened awareness regarding the importance of mathematical modeling research in biology and medicine among several of the National Institutes of Health (NIH). As members will recall we prepared a survey of funding and presented the results in the last newsletter Since that time several announcements have been made by the NIH which are of great interest to the membership.

The most appropriate response to these program announcements is the submission of high quality applications by the membership of the SMB. As Dr. Leon Glass, President of the SMB has emphasized that the NIH will judge the need for funding mathematical biology research applications based on the number and quality of applications that are received. He strongly encourages SMB members who are working in areas that may be eligible for funding under these program announcements to apply for support. The SMB is working to ensure that a pool of qualified reviewers are available to the NIH.

You can easily download the announcements directly from NIH at the URL's listed below. A program announcement from the NIH allows you to apply for grants under the normal NIH cycles, but indicates that your grant is geared to a research area that NIH has announced they are interested in funding. The main homepage for the NIH is http://www.nih.gov.

Information regarding submissions and forms and other information can be found there.

  1. SUPPLEMENTS FOR THE STUDY OF COMPLEX BIOLOGICAL SYSTEMS.

    The purpose of this initiative is to support new quantitative approaches to the study of complex, fundamental biological processes by encouraging non-traditional collaborations across disciplinary lines. The National Institute of General Medical Sciences (NIGMS) will provide supplements to existing NIGMS grants to support the salary and expenses of collaborating investigators such as physicists, engineers, mathematicians, and other experts with quantitative skills relevant to the analysis of complex systems. It is expected that the collaboration will result in new directions for the parent project, or new research projects that will compete for independent funding.

  2. QUANTITATIVE APPROACHES TO THE ANALYSIS OF COMPLEX BIOLOGICAL SYSTEMS.

    The purpose of this program announcement is to advertise National Institute of General Medical Sciences (NIGMS) and National Institute of Mental Health (NIMH) interest in supporting research projects that develop quantitative approaches to describe, analyze, and predict the behavior of complex biological systems, especially those requiring the integration of potentially large amounts of molecular, biochemical, cell biological, and physiological data. Such studies, adapted to the analysis of complex systems in humans, will ultimately have an impact on the treatment of human disorders and disease. These projects are expected to require the participation of individuals with diverse expertise and therefore to be of a collaborative and cross-disciplinary nature. Applicants are strongly encouraged to consider research areas in which systems approaches are likely to make significant contributions. These include NIGMS supported research on basic studies in genetics, biochemistry, neuroscience, cell biology, and developmental biology that typically utilize non-human model systems; basic studies in pharmacology, physiology, metabolic engineering, anesthesiology, and inflammation, burn, and trauma. The NIMH expresses particular interest in studies using mathematical, computational, or theoretical approaches to understanding the fundamental biological mechanisms underlying behavior.

  3. SHORT COURSES ON MATHEMATICAL AND STATISTICAL TOOLS FOR THE STUDY OF COMPLEX PHENOTYPES AND COMPLEX SYSTEMS

    The purpose of this program announcement is to provide support for short courses or workshops to assist scientists in preparing for research on complex phenotypes and complex systems. This award is for scientists studying complex phenotypes and/or complex systems must have strong backgrounds both in biology and in the analysis and interpretation of very complex data. It is important that biologists have a solid understanding of the available mathematical and computational tools so that they can use the tools constructively. Biologists may also require instruction in the language and applications of mathematics and statistics in order to collaborate with mathematicians about biological complexity. Scientists with mathematical skills who wish to apply their knowledge to studies of complexity may also require instruction on the nature, issues, and language of biological research.


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